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Chen Daiwen: Focusing on Intestinal Microorganisms

2019/02/27 18:24
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On April 23, the 3rd Animal Immune Nutrition Conference was held in Nanjing. Vice-President Chen Daiwen of Sichuan Agricultural University made a keynote report on Intestinal Microorganisms at the meeting. Here are some lecture notes arranged by Wang Renjie of DDC Marketing Department.

Animals and microbes are symbionts, for example, there are 1011-12 eukaryotic cells and 1012-13 prokaryotic cells in a pig, so the real animal nutrition should be eukaryotic nutrition plus prokaryotic nutrition. There are three black boxes: host nutritional metabolism and regulation mechanism and genetic interaction; microbial structure, metabolism and host interaction; nutritional structure and its combination effect.

There are 500 to 1000 microorganisms in the digestive tract, and the genome is 100 times higher than that of human genes. In taxonomy, there are 50 bacterial groups, and the intestinal microorganisms are mainly Bacteroides and Thickwalled Bacteria, accounting for more than 90%.

The effects of microorganisms on the intestine:

The results showed that intestinal microorganisms could regulate the angiogenesis of small intestinal villi in mice through Paneth cells. Promote the development of intestinal immune system, promote the development of epithelial gonorrhea cells and goblet cells, produce secretory IgA, and promote the development of peyer's patch (Peyer's lymph node) and MLN (mesenteric lymph node).

Differences in flora types: Different bacteria have different effects on small intestinal morphology.

The effect of bacterial balance: intestinal microorganisms and pathogenic microorganisms have resistance, and imbalance of bacterial flora will lead to intestinal inflammatory diseases.

The effects of microorganisms on body metabolism:

The effect on the metabolism of glucose and lipid: Promote the production of glucose and enhance the lipid-generating effect of liver.

Effect on protein: Promote protein synthesis.

Effects of antibiotics: Inhibiting intestinal microorganisms and reducing intestinal liver protein synthesis.

Possible efficacy of intestinal microorganisms:

Functions: Intestinal structure and functional integrity; immunity and resistance to pathogenic microorganisms; influence the metabolism of glycolipid protein and amino acid.

Effect: Increase nutrient digestibility and absorption rate, reduce emissions, reduce diarrhea and morbidity, and related to nutritional metabolism and quality of animal products.

Regulation of intestinal microorganisms:

Measures to regulate intestinal microorganisms include dietary adjustment (such as different nutrients in the diet, nutrient sources, and additives), probiotics, antibiotics and microbial flora transplantation.

The study found that:

Feed science and technology should attach importance not only to nutritional level, but also to nutritional sources; the essence of nutritional differences is chemical structure, host and microbial utilization; the role of many additives is related to the regulation of intestinal microorganisms, and the development of microecological agents must be based on microecological balance; the essence of nutritional balance is to scientifically solve the needs of host and microorganisms; remember to use tradition or people; To understand and deal with nutritional problems for the sake of ideas.


1. Intestinal microorganisms affect animal health, growth, production and quality, but the interaction mechanism between microorganisms and their hosts remains to be studied.

2. Microecological balance is affected by nutrition and environment, but the structure of microflora, nutritional needs and metabolites are not clear.

3. Nutritional structure determines the nutritional pattern of bacterial flora structure, but the optimum nutritional pattern remains to be studied.